Plasmonic metamaterials provide new opportunities for various inspiring applications. We present multilayer-based plasmonic metamaterials with well-designed hyperbolic dispersions, which provide higher plasmonic density of state. Multilayers with different material and geometry combinations have been fabricated with the thickness of each layer scaled down to a few nanometers by using physical vapor deposition. They have been characterized to further enhance the fluorescence decay rate as compared with single metal films. Other possible applications such as spontaneous recombination rate control, super-resolution imaging, and improved bio-microscopy are also discussed.