META 2021, META'12

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Plasmon Shaping using Molecular Lithography to Engineer Colorimetric Biosensors
Alasdair W Clark

Last modified: 2012-01-03


We report a new plasmonic biosensing technique which allows naked-eye detection of antibody affinity binding at extreme sensitivities. Employing an engineered approach to molecularly-driven plasmonic-coupling, we construct nano-complexes within protein nanoarrays using single biomolecular binding events. Precise molecular positioning of single colloid around pre-fabricated plasmonic nanostructures allows us to manipulate the plasmon supported by each resultant heterodimer to engineer a color-shift which is visible by eye.


Plasmonics; biosensors; molecular lithography; electron beam lithography