15:15 : Molecular Optomechanics with Plasmons: backaction at the nanoscale

Philippe Roelli, Christophe Galland, Nicolas Piro, Tobias Kippenberg

Ecole Polytechnique de Lausanne (Switzerland)

We describe the coupled molecular-plasmonic systems studied in surface- and tip-enhanced Raman scattering as optomechanical cavities. Our theory unravels a hitherto overlooked mechanism: the backaction force of the plasmon on the molecular vibration. Under precise conditions it could lead to coherent amplification of the vibrational motion. This enhancement mechanism could be leveraged to design novel and more efficient sensing systems.
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15:30 : Investigation of amyloidogenic proteins interaction with lipid bilayers using local plasmonic probes

V. Snika (1),L. Ramanauskaite (1),N. Grinceviciute (1),H. Xu (2)

(1)Kaunas University of Technology (Lithuania) , (2)St. John's University (USA)

In this work we investigated the application of novel AFM plasmonic probes for TERS measurements of amyloidogenic proteins deposited on bilayer lipid membranes (BLM). BLMs were formed on the silver nano-wedges decorated substrates for Surface Enhanced Raman Spectroscopy(SERS). The fabricated SERS substrates were found to be an appropriate tool allowing the detection of vibrational fingerprints of BLMs. The idea of the work was the investigation of structural changes of proteins and BLM's determined by their interaction with each other.
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15:45 : Uptake of Liposomal Hybrids in Tumor Cells Using Surface-Enhanced Raman Spectroscopy

Dan Zhu, Zhuyuan Wang, Shenfei Zong, Hui Chen, Peng Chen, Lei Wu, Mingyue Li, Yiping Cui

Southeast University (China)

Understanding the pathways responsible for liposomes internalization into tumor cells is still crucial both from a fundamental point of liposomes and further optimization of liposomes-based intracellular delivery systems. Our study focused on the endocytosis mechanism of nanoparticles functionalized liposomes in the presence of different well-known cellular uptake inhibitors by employing surface-enhanced Raman spectroscopy (SERS). Our results reveal that the liposomal hybrids are taken up by HeLa cells mainly through clathrin-mediated endocytosis (CME), which is an energy-dependent process.
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